Life continues as normal for Natsume - he still lives with the friendly Fujiwaras, walks home with his school friends, and spends his free time adventuring with spirits! However, as his encounters soon reveal, the relationship between spirits and humans is a delicate one and not always friendly either. As Natsume slowly uncovers the mystery of his grandmother Reiko as well as his own unique purpose, can he use the Book of Friends to reconcile the needs of spirits and humans?